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Issue 3, 2016
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Synthetic approaches towards alkaloids bearing α-tertiary amines

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Abstract

Covering: up to August 2015

Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs. Amongst these, the α-tertiary amine (ATA), i.e. a tetrasubstituted carbon atom surrounded by three carbons and one nitrogen, is particularly interesting. A limited number of methods have been described to access this functional group and fewer still are commonly used in synthesis. Herein, we review some approaches to asymmetrically access ATAs and provide an overview of alkaloid total syntheses where those have been employed.

Graphical abstract: Synthetic approaches towards alkaloids bearing α-tertiary amines

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Article information


Submitted
15 Aug 2015
Accepted
29 Oct 2015
First published
01 Dec 2015

This article is Open Access

Nat. Prod. Rep., 2016,33, 491-522
Article type
Review Article
Author version available

Synthetic approaches towards alkaloids bearing α-tertiary amines

A. Hager, N. Vrielink, D. Hager, J. Lefranc and D. Trauner, Nat. Prod. Rep., 2016, 33, 491
DOI: 10.1039/C5NP00096C

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