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Issue 1, 2016
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Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

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Abstract

Covering: 2000 to 2015

While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.

Graphical abstract: Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

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Publication details

The article was received on 04 May 2015 and first published on 26 Oct 2015


Article type: Review Article
DOI: 10.1039/C5NP00050E
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Nat. Prod. Rep., 2016,33, 73-86

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    Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks

    H. Mohimani and P. A. Pevzner, Nat. Prod. Rep., 2016, 33, 73
    DOI: 10.1039/C5NP00050E

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