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Issue 4, 2016
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Post-functionalization of platinum–NHC complexes by oxime ligation for ligand targeted therapy

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Abstract

Carbonyl condensation reactions such as imine, hydrazine, and oxime-bond formation have been successfully used for accessing N-heterocyclic carbene platinum bioconjugate complexes. Among all the synthesized compounds, oxime-containing complexes were found to display a high hydrolytic stability and were found to be stable on silica gel or in wet solvents. As a proof of concept, the Pt NHC complexes were finally functionalized with three selective ligand-targeting moieties using oxime ligation. Preliminary results of the biological effects on various human cancer and non-cancer cells are also reported.

Graphical abstract: Post-functionalization of platinum–NHC complexes by oxime ligation for ligand targeted therapy

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Supplementary files

Article information


Submitted
05 Nov 2015
Accepted
29 Jan 2016
First published
29 Jan 2016

New J. Chem., 2016,40, 3164-3171
Article type
Paper

Post-functionalization of platinum–NHC complexes by oxime ligation for ligand targeted therapy

E. Borré, G. Dahm, G. Guichard and S. Bellemin-Laponnaz, New J. Chem., 2016, 40, 3164
DOI: 10.1039/C5NJ03104D

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