A catalyst free, multicomponent-tandem, facile synthesis of pyrido[2,3-d]pyrimidines using glycerol as a recyclable promoting medium

Abstract

A clean and efficient, multicomponent-tandem strategy for the synthesis of pyrido[2,3-d]pyrimidines is reported in glycerol, a biodegradable and reusable promoting medium. The advantages of the present methodology includes a one-pot catalyst free environmentally friendly approach, 100% atom economy, cost effectiveness, broad substrate scope, operational simplicity, short reaction times, easy workup procedure and high yields.