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Issue 9, 2016
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Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

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Abstract

We know that blood plasma contains many proteins and also other components that bind copper. The largest contributor to copper in the plasma is ceruloplasmin, which accounts for 40–70 percent. Apart from ceruloplasmin and albumin, most of these components have not been studied extensively, and even for ceruloplasmin and albumin, much remains to be discovered. New components with new functions, and new functions of known components are emerging, some warranting reconsideration of earlier findings. The author's laboratory has been actively involved in research on this topic. This review summarizes and updates our knowledge of the nature and functions of ceruloplasmin and the other known and emerging copper-containing molecules (principally proteins) in this fluid, to better understand how they contribute to copper homeostasis and consider their potential significance to health and disease.

Graphical abstract: Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

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Article information


Submitted
25 Apr 2016
Accepted
07 Jul 2016
First published
07 Jul 2016

Metallomics, 2016,8, 887-905
Article type
Critical Review

Ceruloplasmin and other copper binding components of blood plasma and their functions: an update

M. C. Linder, Metallomics, 2016, 8, 887
DOI: 10.1039/C6MT00103C

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