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Issue 9, 2016
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Bacterial Cu+-ATPases: models for molecular structure–function studies

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Abstract

The early discovery of the human Cu+-ATPases and their link to Menkes and Wilson's diseases brought attention to the unique role of these transporters in copper homeostasis. The characterization of bacterial Cu+-ATPases has significantly furthered our understanding of the structure, selectivity and transport mechanism of these enzymes, as well as their interplay with other elements of Cu+ distribution networks. This review focuses on the structural–functional insights that have emerged from studies of bacterial Cu+-ATPases at the molecular level and how these observations have contributed to drawing up a comprehensive picture of cellular copper homeostasis.

Graphical abstract: Bacterial Cu+-ATPases: models for molecular structure–function studies

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Publication details

The article was received on 01 Apr 2016, accepted on 22 Jul 2016 and first published on 22 Jul 2016


Article type: Critical Review
DOI: 10.1039/C6MT00089D
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Metallomics, 2016,8, 906-914

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    Bacterial Cu+-ATPases: models for molecular structure–function studies

    J. M. Argüello, S. J. Patel and J. Quintana, Metallomics, 2016, 8, 906
    DOI: 10.1039/C6MT00089D

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