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Issue 9, 2016
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A ratiometric fluorescent sensor for the mitochondrial copper pool

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Abstract

Copper plays a key role in the modulation of cellular function, defence, and growth. Here we present InCCu1, a ratiometric fluorescent sensor for mitochondrial copper, which changes from red to blue emission in the presence of Cu(I). Employing this probe in microscopy and flow cytometry, we show that cisplatin-treated cells have an impaired ability to accumulate copper in the mitochondria.

Graphical abstract: A ratiometric fluorescent sensor for the mitochondrial copper pool

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Publication details

The article was received on 31 Mar 2016, accepted on 19 Aug 2016 and first published on 23 Aug 2016


Article type: Communication
DOI: 10.1039/C6MT00083E
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Metallomics, 2016,8, 915-919

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    A ratiometric fluorescent sensor for the mitochondrial copper pool

    C. Shen, J. L. Kolanowski, C. M.-N. Tran, A. Kaur, M. C. Akerfeldt, M. S. Rahme, T. W. Hambley and E. J. New, Metallomics, 2016, 8, 915
    DOI: 10.1039/C6MT00083E

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