Jump to main content
Jump to site search

Issue 6, 2016
Previous Article Next Article

Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

Author affiliations

Abstract

Childhood lead poisoning is a costly and largely preventable public health problem that lowers IQs, decreases attention spans, and leads to the development of other childhood intellectual disabilities. Furthermore, recent evidence links developmental lead poisoning with the etiology of disorders that appear much later in life, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Little is known about how lead influences the onset of these disorders. This paper reviews the evidence that lead substitution for zinc in zinc-finger proteins contributes to the development of Alzheimer's disease, Parkinson's disease, and schizophrenia. The zinc-finger proteins potentially impacted by lead include DNA methyltransferase 1 (DNMT1) and Presenilin 1 and 2 (PSEN1/2) in Alzheimer's disease, the dopamine receptor in Parkinson's disease, and the NMDA receptor, zinc-finger protein 804A (ZNF804A), and disrupted-in-schizophrenia 1 (DISC1)-binding zinc-finger (DBZ) in schizophrenia.

Graphical abstract: Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

Back to tab navigation

Publication details

The article was received on 23 Nov 2015, accepted on 21 Dec 2015 and first published on 24 Dec 2015


Article type: Critical Review
DOI: 10.1039/C5MT00300H
Citation: Metallomics, 2016,8, 579-588

  •   Request permissions

    Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health

    J. M. Ordemann and R. N. Austin, Metallomics, 2016, 8, 579
    DOI: 10.1039/C5MT00300H

Search articles by author

Spotlight

Advertisements