Issue 5, 2016
From the journal:

Materials Horizons

Mechanochemical functionalization of disulfide linked hydrogels†

Junmin Lee,a   Meredith N. Silberstein,b   Amr A. Abdeen,a   Sang Yup Kimc  and  Kristopher A. Kilian*a  

* Corresponding authors

a Department of Materials Science and Engineering and Micro and Nanotechnology Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
E-mail: kakilian@illinois.edu

b Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA

c Department of Aerospace Engineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA

Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Graphical abstract: Mechanochemical functionalization of disulfide linked hydrogels

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Article information

DOI
https://doi.org/10.1039/C6MH00091F
Article type
Communication
Submitted
30 Mar 2016
Accepted
26 May 2016
First published
02 Jun 2016

Mater. Horiz., 2016,3, 447-451

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Mechanochemical functionalization of disulfide linked hydrogels

J. Lee, M. N. Silberstein, A. A. Abdeen, S. Y. Kim and K. A. Kilian, Mater. Horiz., 2016, 3, 447 DOI: 10.1039/C6MH00091F

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