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Issue 11, 2016
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Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

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Abstract

The Hsp90 chaperone is a promising target for the treatment of cancer. Well known inhibitors, e.g. geldanamycin, radicicol, novobiocin and their derivatives, have been extensively investigated and optimized as inhibitors of Hsp90. More recently, new chemotypes of natural origin were reported to modulate Hsp90 function via various and often “non-conventional” mechanisms. This review focuses on these novel classes of natural products whose structures have not yet been thoroughly explored for medicinal chemistry purposes. These novel chemotypes may constitute interesting starting points for future drug discovery campaigns.

Graphical abstract: Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

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Article information


Submitted
17 Jun 2016
Accepted
12 Jul 2016
First published
13 Jul 2016

Med. Chem. Commun., 2016,7, 2063-2075
Article type
Review Article

Novel and less explored chemotypes of natural origin for the inhibition of Hsp90

F. Pellati and G. Rastelli, Med. Chem. Commun., 2016, 7, 2063
DOI: 10.1039/C6MD00340K

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