Jump to main content
Jump to site search

Issue 8, 2016
Previous Article Next Article

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Author affiliations

Abstract

Fluorine is a highly attractive element for both medicinal chemistry and imaging technologies. To facilitate protein tyrosine phosphatase (PTP)-targeted drug discovery and imaging-guided PTP research on fluorine, several highly potent and 19F MR sensitive PTP inhibitors were discovered through a structure-based focused library strategy.

Graphical abstract: Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Back to tab navigation

Supplementary files

Article information


Submitted
21 May 2016
Accepted
17 Jun 2016
First published
20 Jun 2016

Med. Chem. Commun., 2016,7, 1672-1680
Article type
Research Article

Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors

Y. Li, G. Xia, Q. Guo, L. Wu, S. Chen, Z. Yang, W. Wang, Z. Zhang, X. Zhou and Z. Jiang, Med. Chem. Commun., 2016, 7, 1672
DOI: 10.1039/C6MD00277C

Search articles by author

Spotlight

Advertisements