Jump to main content
Jump to site search

Issue 9, 2016
Previous Article Next Article

The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone

Author affiliations

Abstract

Plants can develop multifaceted system resistance as a result of infection with pathogens, insects, and some specific microbes or after treatment with specific chemicals.1 Among them, systemic acquired resistance (SAR) and induced systemic resistance (ISR)2 are the two most important types. To activate them, a large number of chemical inducers have been exploited based on the SA pathway. However, the JA pathway was rarely investigated for new plant activators. In this study, starting from JA and its analogs, based on the molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound, pyrrolidone, as a new scaffold of plant activators was predicted and a series of 1-phenyl-5-pyrrolidone-3-carboxylic acid derivatives were designed and synthesized. The bioactivity was evaluated, and most of the compounds showed satisfactory activity; especially, compounds 7–11 showed almost no in vitro activity but excellent efficacy against tested diseases, and the prediction of the virtual screening results was also confirmed, which promoted the application of SHAFTS in the development of pesticides.

Graphical abstract: The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 May 2016, accepted on 21 Jun 2016 and first published on 22 Jun 2016


Article type: Research Article
DOI: 10.1039/C6MD00261G
Med. Chem. Commun., 2016,7, 1849-1857

  •   Request permissions

    The discovery of new plant activators and scaffolds with potential induced systemic resistance: from jasmonic acid to pyrrolidone

    K. Chang, Y. Shi, J. Chen, Z. He, Z. Xu, Z. Zhao, W. Zhu, H. Li, Y. Xu, B. Li and X. Qian, Med. Chem. Commun., 2016, 7, 1849
    DOI: 10.1039/C6MD00261G

Search articles by author

Spotlight

Advertisements