Jump to main content
Jump to site search

Issue 8, 2016
Previous Article Next Article

The biogenic amine transporter activity of vinylogous amphetamine analogs

Author affiliations

Abstract

A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (DA/5-HT) releaser with no activity at 5-HT2 receptors. This unique profile of actions suggests that analog S-6 is a viable lead compound for identifying new structural classes of DA/5-HT releasers with therapeutic benefit and reduced abuse liability.

Graphical abstract: The biogenic amine transporter activity of vinylogous amphetamine analogs

Back to tab navigation

Supplementary files

Article information


Submitted
30 Apr 2016
Accepted
06 Jun 2016
First published
30 Jun 2016

Med. Chem. Commun., 2016,7, 1657-1663
Article type
Research Article

The biogenic amine transporter activity of vinylogous amphetamine analogs

A. M. Decker, J. S. Partilla, M. H. Baumann, R. B. Rothman and B. E. Blough, Med. Chem. Commun., 2016, 7, 1657
DOI: 10.1039/C6MD00245E

Search articles by author

Spotlight

Advertisements