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Issue 9, 2016
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Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

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Abstract

Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.

Graphical abstract: Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

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Supplementary files

Article information


Submitted
26 Apr 2016
Accepted
12 Jul 2016
First published
21 Jul 2016

This article is Open Access

Med. Chem. Commun., 2016,7, 1797-1801
Article type
Research Article

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

J. Lehmann, J. Vomacka, K. Esser, M. Nodwell, K. Kolbe, P. Rämer, U. Protzer, N. Reiling and S. A. Sieber, Med. Chem. Commun., 2016, 7, 1797
DOI: 10.1039/C6MD00231E

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