Issue 9, 2016
From the journal:

MedChemComm

Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases†‡

J. Lehmann,§a   J. Vomacka, ORCID logo §a   K. Esser,§b   M. Nodwell,a   K. Kolbe,c   P. Rämer,d   U. Protzer,be   N. Reiling*c  and  S. A. Sieber*a  

* Corresponding authors

a Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching, Germany
E-mail: stephan.sieber@tum.de

b Institut für Virologie, Technische Universität München/Helmholtz Zentrum München, Trogerstraße 30, 81675 München, Germany

c Forschungszentrum Borstel, Leibniz-Zentrum für Medizin und Biowissenschaften, FG Mikrobielle Grenzflächenbiologie, Parkallee 22, 23845 Borstel, Germany
E-mail: nreiling@fz-borstel.de

d Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstraße 30, 81675 München, Germany

e German Center for Infection Research (DZIF), Munich partner site, Germany

Abstract

Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.

Graphical abstract: Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

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Article information

DOI
https://doi.org/10.1039/C6MD00231E
Article type
Research Article
Submitted
26 Apr 2016
Accepted
12 Jul 2016
First published
21 Jul 2016
This article is Open Access
Creative Commons BY license

Med. Chem. Commun., 2016,7, 1797-1801

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Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases

J. Lehmann, J. Vomacka, K. Esser, M. Nodwell, K. Kolbe, P. Rämer, U. Protzer, N. Reiling and S. A. Sieber, Med. Chem. Commun., 2016, 7, 1797 DOI: 10.1039/C6MD00231E

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