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Issue 5, 2016
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Label-free technologies for target identification and validation

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Phenotypic screening is a powerful strategy for identifying active molecules with particular biological effects in cellular or animal disease models. Functionalized chemical probes have been instrumental in revealing new targets and confirming target engagement. However, substantial effort and resources are required to design and synthesize these bioactive probes. In contrast, label-free technologies have the advantage of bypassing the need for chemical probes. Here we highlight the recent developments in label-free methods and discuss the strengths and limitations of each approach.

Graphical abstract: Label-free technologies for target identification and validation

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The article was received on 21 Jan 2016, accepted on 20 Mar 2016 and first published on 22 Mar 2016

Article type: Review Article
DOI: 10.1039/C6MD00045B
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Citation: Med. Chem. Commun., 2016,7, 769-777

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    Label-free technologies for target identification and validation

    J. Li, H. Xu, G. M. West and L. H. Jones, Med. Chem. Commun., 2016, 7, 769
    DOI: 10.1039/C6MD00045B

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