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Issue 3, 2016
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Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

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Abstract

Rigid amphipathic fusion inhibitors (RAFIs), 5-arylethynyl uracil nucleosides with bulky aryl groups, appeared to have considerable activity against tick-borne encephalitis virus (TBEV) in cell culture. The rigid ethynyl linker and perylene residue are essential structural prerequisites for high activity, giving EC50 values of 18 and 24 nM for 5-(perylen-3-yl)ethynyl-arabino-uridine and 5-(perylen-3-yl)ethynyl-2′-deoxy-uridine, respectively, upon simultaneous mixing of the compounds, cells and virus.

Graphical abstract: Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

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Submitted
20 Nov 2015
Accepted
18 Dec 2015
First published
21 Dec 2015

Med. Chem. Commun., 2016,7, 495-499
Article type
Research Article

Rigid amphipathic nucleosides suppress reproduction of the tick-borne encephalitis virus

A. A. Orlov, A. A. Chistov, L. I. Kozlovskaya, A. V. Ustinov, V. A. Korshun, G. G. Karganova and D. I. Osolodkin, Med. Chem. Commun., 2016, 7, 495
DOI: 10.1039/C5MD00538H

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