Jump to main content
Jump to site search

Issue 3, 2016
Previous Article Next Article

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

Author affiliations

Abstract

The combination of flow chemistry and computational tools has been successfully applied to prepare a focused library of tricyclic tetrahydroquinolines endowed with drug-like properties. The study illustrates the efficient synthesis of this class of compounds using flow mesoreactors in a multicomponent fashion, as well as the profitable employment of computational chemistry for library diversity analysis. Early biological characterization of selected compounds of the library are also presented for the discovery of novel chemical probes to unravel estrogen receptor signaling pathways.

Graphical abstract: Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

Back to tab navigation

Supplementary files

Article information


Submitted
05 Oct 2015
Accepted
05 Nov 2015
First published
16 Nov 2015

Med. Chem. Commun., 2016,7, 439-446
Article type
Research Article

Integrating multicomponent flow synthesis and computational approaches for the generation of a tetrahydroquinoline compound based library

B. Cerra, S. Mostarda, C. Custodi, A. Macchiarulo and A. Gioiello, Med. Chem. Commun., 2016, 7, 439
DOI: 10.1039/C5MD00455A

Search articles by author

Spotlight

Advertisements