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Issue 9, 2016
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New approaches and omics tools for mining of vaccine candidates against vector-borne diseases

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Abstract

Vector-borne diseases (VBDs) present a major threat to human and animal health, as well as place a substantial burden on livestock production. As a way of sustainable VBD control, focus is set on vaccine development. Advances in genomics and other “omics” over the past two decades have given rise to a “third generation” of vaccines based on technologies such as reverse vaccinology, functional genomics, immunomics, structural vaccinology and the systems biology approach. The application of omics approaches is shortening the time required to develop the vaccines and increasing the probability of discovery of potential vaccine candidates. Herein, we review the development of new generation vaccines for VBDs, and discuss technological advancement and overall challenges in the vaccine development pipeline. Special emphasis is placed on the development of anti-tick vaccines that can quell both vectors and pathogens.

Graphical abstract: New approaches and omics tools for mining of vaccine candidates against vector-borne diseases

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Article information


Submitted
08 Apr 2016
Accepted
19 Jun 2016
First published
20 Jun 2016

Mol. BioSyst., 2016,12, 2680-2694
Article type
Review Article

New approaches and omics tools for mining of vaccine candidates against vector-borne diseases

J. Kuleš, A. Horvatić, N. Guillemin, A. Galan, V. Mrljak and M. Bhide, Mol. BioSyst., 2016, 12, 2680
DOI: 10.1039/C6MB00268D

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