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Issue 5, 2016
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Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

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Abstract

The pH gating of human AQP3 and its effects on both water and glycerol permeabilities have been fully characterized for the first time using a human red blood cell model (hRBC). For comparison, the effects of pH on the gating of rat AQP3 have also been characterized in yeast. The obtained results highlight similarities as well as differences between the two isoforms. In addition, we investigated the molecular mechanism of hAQP3 pH gating in silico, which may disclose new pathways to AQP regulation by small molecule inhibitors, and therefore may be important for drug development.

Graphical abstract: Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

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Supplementary files

Article information


Submitted
06 Jan 2016
Accepted
02 Mar 2016
First published
02 Mar 2016

Mol. BioSyst., 2016,12, 1564-1573
Article type
Paper

Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?

A. de Almeida, A. P. Martins, A. F. Mósca, H. J. Wijma, C. Prista, G. Soveral and A. Casini, Mol. BioSyst., 2016, 12, 1564
DOI: 10.1039/C6MB00013D

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