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Issue 14, 2016
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Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges

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Abstract

This review targets diversified oligonucleotide-based biodetection techniques, focusing on the use of microresonators of whispering gallery mode (WGM) type as optical biosensors mostly integrated with lab-on-a-chip systems. On-chip and microfluidics combined devices along with optical microresonators provide rapid, robust, reproducible and multiplexed biodetection abilities in considerably small volumes. We present a detailed overview of the studies conducted so far, including biodetection of various oligonucleotide biomarkers as well as deoxyribonucleic acids (DNAs), ribonucleic acids (RNAs) and proteins. We particularly advert to chemical surface modifications for specific and selective biosensing.

Graphical abstract: Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges

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Article information


Submitted
19 Apr 2016
Accepted
31 May 2016
First published
31 May 2016

Lab Chip, 2016,16, 2572-2595
Article type
Critical Review

Oligonucleotide-based label-free detection with optical microresonators: strategies and challenges

P. Toren, E. Ozgur and M. Bayindir, Lab Chip, 2016, 16, 2572
DOI: 10.1039/C6LC00521G

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