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Issue 7, 2016

A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor

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Abstract

A surface acoustic wave (SAW)-enhanced, surface plasmon resonance (SPR) microfluidic biosensor in which SAW-induced mixing and phase-interrogation grating-coupling SPR are combined in a single lithium niobate lab-on-a-chip is demonstrated. Thiol-polyethylene glycol adsorption and avidin/biotin binding kinetics were monitored by exploiting the high sensitivity of grating-coupling SPR under azimuthal control. A time saturation binding kinetics reduction of 82% and 24% for polyethylene and avidin adsorption was obtained, respectively, due to the fluid mixing enhancement by means of the SAW-generated chaotic advection. These results represent the first implementation of a nanostructured SAW–SPR microfluidic biochip capable of significantly improving the molecule binding kinetics on a single, portable device. In addition, the biochip here proposed is suitable for a great variety of biosensing applications.

Graphical abstract: A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor

Supplementary files

Article information


Submitted
14 Jan 2016
Accepted
15 Feb 2016
First published
15 Feb 2016

Lab Chip, 2016,16, 1224-1233
Article type
Paper

A surface acoustic wave (SAW)-enhanced grating-coupling phase-interrogation surface plasmon resonance (SPR) microfluidic biosensor

A. Sonato, M. Agostini, G. Ruffato, E. Gazzola, D. Liuni, G. Greco, M. Travagliati, M. Cecchini and F. Romanato, Lab Chip, 2016, 16, 1224 DOI: 10.1039/C6LC00057F

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