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Issue 5, 2016
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Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis

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Abstract

Programmable microfluidic platforms (PMPs) are enabling significant advances in the utility of microfluidics for chemical and biochemical analysis. Traditional microfluidic devices are analogous to application-specific devices – a new device is needed to implement each new chemical or biochemical assay. PMPs are analogous to digital electronic processors – all that is needed to implement a new assay is a change in the order of operations conducted by the device. In this review, we introduce PMPs based on normally-closed microvalves. We discuss recent applications of PMPs in diverse fields including genetic analysis, antibody-based biomarker analysis, and chemical analysis in planetary exploration. Prospects, challenges, and future concepts for this emerging technology will also be presented.

Graphical abstract: Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis

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Article information


Submitted
13 Nov 2015
Accepted
02 Feb 2016
First published
03 Feb 2016

Lab Chip, 2016,16, 812-819
Article type
Critical Review

Pneumatically actuated microvalve circuits for programmable automation of chemical and biochemical analysis

J. Kim, A. M. Stockton, E. C. Jensen and R. A. Mathies, Lab Chip, 2016, 16, 812
DOI: 10.1039/C5LC01397F

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