Issue 4, 2017
From the journal:

Green Chemistry

Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions†

Katharina J. Hock,‡a   Lucas Mertens,‡a   Friederike K. Metze,a   Clemens Schmittmanna  and  Rene M. Koenigs ORCID logo *a  

* Corresponding authors

a RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, D-52074 Aachen, Germany
E-mail: rene.koenigs@rwth-aachen.de

Abstract

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.

Graphical abstract: Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

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Article information

DOI
https://doi.org/10.1039/C6GC03187K
Article type
Communication
Submitted
18 Nov 2016
Accepted
14 Dec 2016
First published
15 Dec 2016
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2017,19, 905-909

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Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

K. J. Hock, L. Mertens, F. K. Metze, C. Schmittmann and R. M. Koenigs, Green Chem., 2017, 19, 905 DOI: 10.1039/C6GC03187K

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