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Issue 4, 2017
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Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

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Abstract

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.

Graphical abstract: Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

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Publication details

The article was received on 18 Nov 2016, accepted on 14 Dec 2016 and first published on 15 Dec 2016


Article type: Communication
DOI: 10.1039/C6GC03187K
Green Chem., 2017,19, 905-909
  • Open access: Creative Commons BY-NC license
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    Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

    K. J. Hock, L. Mertens, F. K. Metze, C. Schmittmann and R. M. Koenigs, Green Chem., 2017, 19, 905
    DOI: 10.1039/C6GC03187K

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