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Issue 15, 2016
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A metal-free transformation of alkynes to carbonyls directed by remote OH group

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Abstract

A remote OH group-directed metal-free transformation of alkynes to carbonyl compounds has been developed. Using only HOAc and EtOH solvent, this reaction elegantly converts alkynes into valuable ketones by remote hydroxyl group activation. Through comparison and isotope labeling experiments, it was confirmed that the process operates via a hydration reaction involving an acetic acid molecule, instead of a water molecule.

Graphical abstract: A metal-free transformation of alkynes to carbonyls directed by remote OH group

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Article information


Submitted
22 Apr 2016
Accepted
20 Jun 2016
First published
21 Jun 2016

Green Chem., 2016,18, 4176-4180
Article type
Communication
Author version available

A metal-free transformation of alkynes to carbonyls directed by remote OH group

D. Chen, C. Guo, H. Zhang, D. Jin, X. Li, P. Gao, X. Wu, X. Liu and Y. Liang, Green Chem., 2016, 18, 4176
DOI: 10.1039/C6GC01141A

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