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Issue 15, 2016
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A metal-free transformation of alkynes to carbonyls directed by remote OH group

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Abstract

A remote OH group-directed metal-free transformation of alkynes to carbonyl compounds has been developed. Using only HOAc and EtOH solvent, this reaction elegantly converts alkynes into valuable ketones by remote hydroxyl group activation. Through comparison and isotope labeling experiments, it was confirmed that the process operates via a hydration reaction involving an acetic acid molecule, instead of a water molecule.

Graphical abstract: A metal-free transformation of alkynes to carbonyls directed by remote OH group

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Publication details

The article was received on 22 Apr 2016, accepted on 20 Jun 2016 and first published on 21 Jun 2016


Article type: Communication
DOI: 10.1039/C6GC01141A
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Green Chem., 2016,18, 4176-4180

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    A metal-free transformation of alkynes to carbonyls directed by remote OH group

    D. Chen, C. Guo, H. Zhang, D. Jin, X. Li, P. Gao, X. Wu, X. Liu and Y. Liang, Green Chem., 2016, 18, 4176
    DOI: 10.1039/C6GC01141A

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