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Issue 10, 2016
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Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition

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Abstract

Mangiferin is a natural xanthone glycoside with therapeutic potential. Herein, its cytotoxic properties were explored in a human cell model of breast adenocarcinoma. The results supported the multi-target nature of mangiferin action, as the inhibition of three enzymatic systems, namely HMG-CoA reductase, the proteasome and plasmin, respectively in charge of regulating cholesterol homeostasis, protein turnover and cell adhesion, was documented for the first time. Globally, mangiferin was able to selectively block breast cancer cell growth by inducing apoptosis and by arresting cell proliferation through a combined action on cholesterol and proteasome pathways, as well as to inhibit plasmin-mediated mechanisms of cell migration.

Graphical abstract: Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition

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Supplementary files

Article information


Submitted
11 Jul 2016
Accepted
25 Aug 2016
First published
26 Aug 2016

Food Funct., 2016,7, 4299-4309
Article type
Paper

Mangiferin blocks proliferation and induces apoptosis of breast cancer cells via suppression of the mevalonate pathway and by proteasome inhibition

M. Cuccioloni, L. Bonfili, M. Mozzicafreddo, V. Cecarini, S. Scuri, M. Cocchioni, M. Nabissi, G. Santoni, A. M. Eleuteri and M. Angeletti, Food Funct., 2016, 7, 4299
DOI: 10.1039/C6FO01037G

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