Issue 10, 2016
From the journal:

Food & Function

δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling

Gregor Carpentero Burdeos,a   Junya Ito,a   Takahiro Eitsuka,b   Kiyotaka Nakagawa,*a   Fumiko Kimuraa  and  Teruo Miyazawaac  

* Corresponding authors

a Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Sciences, Tohoku University, Sendai, Japan
E-mail: nkgw@m.tohoku.ac.jp

b Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan

c Food and Biotechnology Innovation Project, New Industry Creation Hatchery Center (NICHe), Tohoku University, Sendai, Japan

Abstract

Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway.

Graphical abstract: δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling

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Article information

DOI
https://doi.org/10.1039/C6FO00826G
Article type
Communication
Submitted
04 Jun 2016
Accepted
15 Sep 2016
First published
16 Sep 2016

Food Funct., 2016,7, 4170-4174

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δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling

G. C. Burdeos, J. Ito, T. Eitsuka, K. Nakagawa, F. Kimura and T. Miyazawa, Food Funct., 2016, 7, 4170 DOI: 10.1039/C6FO00826G

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