Jump to main content
Jump to site search

Issue 8, 2016
Previous Article Next Article

Designing food delivery systems: challenges related to the in vitro methods employed to determine the fate of bioactives in the gut

Author affiliations

Abstract

An in depth understanding of the underpinning mechanisms that relate to food disruption and processing in the gastrointestinal tract is necessary to achieve optimal intake of nutrients and their bioefficacy. Although in vivo trials can provide insights on physiological responses of nutrients, in vitro assays are often applied as tools to understand specific mechanisms, or as prescreening methods to determine the factors associated with the uptake of food components in the gastrointestinal tract. In vitro assays are also often utilized to design novel or improved food delivery systems. In this review the available approaches to study delivery and uptake of food bioactives and the associated challenges are discussed. For an in depth understanding of food processing in the gastrointestinal tract, it is necessary to apply multidisciplinary methodologies, at the interface between materials science, chemistry, physics and biology.

Graphical abstract: Designing food delivery systems: challenges related to the in vitro methods employed to determine the fate of bioactives in the gut

Back to tab navigation

Article information


Submitted
22 Feb 2016
Accepted
16 Apr 2016
First published
18 Apr 2016

Food Funct., 2016,7, 3319-3336
Article type
Review Article

Designing food delivery systems: challenges related to the in vitro methods employed to determine the fate of bioactives in the gut

E. Arranz, M. Corredig and A. Guri, Food Funct., 2016, 7, 3319
DOI: 10.1039/C6FO00230G

Social activity

Search articles by author

Spotlight

Advertisements