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Volume 187, 2016
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Infrared micro-spectroscopy of human tissue: principles and future promises

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Abstract

This article summarizes the methods employed, and the progress achieved over the past two decades in applying vibrational (Raman and IR) micro-spectroscopy to problems of medical diagnostics and cellular biology. During this time, several research groups have verified the enormous information contained in vibrational spectra; in fact, information on protein, lipid and metabolic composition of cells and tissues can be deduced by decoding the observed vibrational spectra. This decoding process is aided by the availability of computer workstations and advanced algorithms for data analysis. Furthermore, commercial instrumentation for the fast collection of both Raman and infrared micro-spectral data has enabled the collection of images of cells and tissues based solely on vibrational spectroscopic data. The progress in the field has been manifested by a steady increase in the number and quality of publications submitted by established and new research groups in vibrational spectroscopy in the biological and biomedical arenas.

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Publication details

The article was received on 23 Feb 2016, accepted on 14 Mar 2016 and first published on 14 Mar 2016


Article type: Paper
DOI: 10.1039/C6FD00023A
Faraday Discuss., 2016,187, 9-42

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    Infrared micro-spectroscopy of human tissue: principles and future promises

    M. Diem, A. Ergin, S. Remiszewski, X. Mu, A. Akalin and D. Raz, Faraday Discuss., 2016, 187, 9
    DOI: 10.1039/C6FD00023A

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