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Issue 28, 2016
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Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity

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Abstract

Platinum(II) N-heterocyclic carbene complexes have been oxidized by bromine or iodobenzene dichloride to provide the fully characterised corresponding platinum(IV) NHC complexes. Antiproliferative activities of Pt(IV) NHC complexes were assayed against several cancer cell lines and the results were correlated with respect to their stability. Mechanistic investigations revealed that mitochondrial dysfunction and ROS production were associated with the cytotoxic process induced by these compounds.

Graphical abstract: Platinum(iv) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity

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Article information


Submitted
10 May 2016
Accepted
10 Jun 2016
First published
13 Jun 2016

Dalton Trans., 2016,45, 11362-11368
Article type
Paper

Platinum(IV) N-heterocyclic carbene complexes: their synthesis, characterisation and cytotoxic activity

M. Bouché, G. Dahm, M. Wantz, S. Fournel, T. Achard and S. Bellemin-Laponnaz, Dalton Trans., 2016, 45, 11362
DOI: 10.1039/C6DT01846G

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