Issue 16, 2016

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Abstract

Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.

Graphical abstract: Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2016
Accepted
16 Feb 2016
First published
17 Feb 2016

Dalton Trans., 2016,45, 6812-6815

Author version available

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Stephanie. J. Lucas, R. M. Lord, A. M. Basri, S. J. Allison, R. M. Phillips, A. J. Blacker and P. C. McGowan, Dalton Trans., 2016, 45, 6812 DOI: 10.1039/C6DT00186F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements