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Issue 15, 2016
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Scaling-down antibody radiolabeling reactions with zirconium-89

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Abstract

The most widely cited procedures for radiolabeling antibodies with zirconium-89 for immuno-PET require multi-milligram amounts of antibody which can be cost-prohibitive, particularly during the research and development process. We therefore sought to develop a reliable 89Zr-radiolabeling procedure that provides high radiochemical yields at the microgram scale.

Graphical abstract: Scaling-down antibody radiolabeling reactions with zirconium-89

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Supplementary files

Article information


Submitted
07 Dec 2015
Accepted
07 Mar 2016
First published
11 Mar 2016

Dalton Trans., 2016,45, 6343-6347
Article type
Communication
Author version available

Scaling-down antibody radiolabeling reactions with zirconium-89

J. C. Knight, S. J. Paisey, A. M. Dabkowski, C. Marculescu, A. S. Williams, C. Marshall and B. Cornelissen, Dalton Trans., 2016, 45, 6343
DOI: 10.1039/C5DT04774A

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