Issue 13, 2016

Cu-catalysed pyrazole synthesis in continuous flow


The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow conditions using prepacked stainless steel cartridges containing the solid-supported copper promoter. Finally, we demonstrate that this synthetic procedure can be successfully scaled up to produce practically useful amounts of pyrazole products within 2–5 hours.

Graphical abstract: Cu-catalysed pyrazole synthesis in continuous flow

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Article information

Article type
23 Dec 2015
06 Feb 2016
First published
08 Feb 2016
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2016,6, 4718-4723

Cu-catalysed pyrazole synthesis in continuous flow

J. Comas-Barceló, D. Blanco-Ania, S. A. M. W. van den Broek, P. J. Nieuwland, J. P. A. Harrity and F. P. J. T. Rutjes, Catal. Sci. Technol., 2016, 6, 4718 DOI: 10.1039/C5CY02247A

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