Trifluoromethylation of thiophenols and thiols with sodium trifluoromethanesulfinate and iodine pentoxide†
Abstract
A selective and facile trifluoromethylation process for a wide range of thiophenols and thiols under metal free conditions has been developed using two simple and safe solids, sodium trifluoro-methanesulfinate and iodine pentoxide, via the radical process.