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Issue 22, 2016
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Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

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Abstract

The fluorination of organic molecules is a rapidly evolving and exciting field in synthesis, which still poses huge challenges despite the advances made in the past decades. Hypervalent iodine(III) reagents, which have already proven their versatility as synthetic tools in organic chemistry, are currently on the rise in fluorination chemistry. With their ability to break new mechanistic grounds, they grant access to completely new reactivities and thus also to novel fluorinated structural scaffolds. This review aims to provide an overview of the achievements made in the iodine(III) mediated fluorinations of aliphatic Csp2–carbon atoms with special focus on the opportunities provided by this exciting class of hypervalent substances.

Graphical abstract: Hypervalent iodine(iii) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

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Article information


Submitted
06 May 2016
First published
15 Jul 2016

Chem. Soc. Rev., 2016,45, 6270-6288
Article type
Review Article

Hypervalent iodine(III) fluorinations of alkenes and diazo compounds: new opportunities in fluorination chemistry

S. V. Kohlhepp and T. Gulder, Chem. Soc. Rev., 2016, 45, 6270
DOI: 10.1039/C6CS00361C

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