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Issue 8, 2016
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Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

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Abstract

The employment of continuous-flow platforms for synthetic chemistry is becoming increasingly popular in research and industrial environments. Integrating analytics in-line enables obtaining a large amount of information in real-time about the reaction progress, catalytic activity and stability, etc. Furthermore, it is possible to influence the reaction progress and selectivity via manual or automated feedback optimisation, thus constituting a dial-a-molecule approach employing digital synthesis. This contribution gives an overview of the most significant contributions in the field to date.

Graphical abstract: Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

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Article information


Submitted
21 Oct 2015
First published
27 Jan 2016

Chem. Soc. Rev., 2016,45, 2032-2043
Article type
Tutorial Review

Towards dial-a-molecule by integrating continuous flow, analytics and self-optimisation

V. Sans and L. Cronin, Chem. Soc. Rev., 2016, 45, 2032
DOI: 10.1039/C5CS00793C

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