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Issue 22, 2016
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Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

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Abstract

The phase behavior of a mixture of a typical insect pheromone (olean) and a phospholipid (DOPC)/water dispersion is extensively explored through SAXS, NMR and DSC experiments. The results mimic those obtained with anaesthetics in phospholipid/water systems. They also mimic the behavior and microstructure of ternary mixtures of a membrane mimetic, bilayer-forming double chained surfactants, oils and water. Taken together with recent models for conduction of the nervous impulse, all hint at lipid involvement and the underlying unity in mechanisms of pheromone, anaesthetic and hydrophobic drugs, where a local phase change in the lipid membrane architecture may be at least partly involved in the transmission of the signal.

Graphical abstract: Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

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Article information


Submitted
29 Jan 2016
Accepted
06 May 2016
First published
06 May 2016

Phys. Chem. Chem. Phys., 2016,18, 15375-15383
Article type
Paper
Author version available

Phase transitions in hydrophobe/phospholipid mixtures: hints at connections between pheromones and anaesthetic activity

S. Borsacchi, M. Geppi, S. Macchi, B. W. Ninham, E. Fratini, M. Ambrosi, P. Baglioni and P. Lo Nostro, Phys. Chem. Chem. Phys., 2016, 18, 15375
DOI: 10.1039/C6CP00659K

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