Cysteine containing dipeptides show a metal specificity that matches the composition of seawater†
Model prebiotic dipeptide sequences were identified by bioinformatics and DFT and molecular dynamics calculations. The peptides were then synthesized and evaluated for metal affinity and specificity. Cysteine containing dipeptides were not associated with metal affinities that followed the Irving–Williams series but did follow the concentration trends found in seawater.
- This article is part of the themed collections: Celebrating our 2019 Prize and Award winners and Prebiotic chemistry and the molecular origins of life