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Issue 6, 2017
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Rotaxane probes for protease detection by 129Xe hyperCEST NMR

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Abstract

We report a CB6 rotaxane for the 129Xe hyperCEST NMR detection of matrix metalloprotease 2 (MMP-2) activity. MMP-2 is overexpressed in cancer tissue, and hence is a cancer marker. A peptide containing an MMP-2 recognition sequence was incorporated into the rotaxane, synthesized via CB6-promoted click chemistry. Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for 129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation.

Graphical abstract: Rotaxane probes for protease detection by 129Xe hyperCEST NMR

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Publication details

The article was received on 21 Nov 2016, accepted on 15 Dec 2016 and first published on 15 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC09302G
Citation: Chem. Commun., 2017,53, 1076-1079

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    Rotaxane probes for protease detection by 129Xe hyperCEST NMR

    C. C. Slack, J. A. Finbloom, K. Jeong, C. J. Bruns, D. E. Wemmer, A. Pines and M. B. Francis, Chem. Commun., 2017, 53, 1076
    DOI: 10.1039/C6CC09302G

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