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Issue 6, 2017
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Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

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Abstract

DNA aptamers that enhance calcium phosphate mineral formation were identified using a novel precipitation SELEX method. The evolved DNA library was substantially enriched in G nucleotides and in predicted G-quadruplex structures, suggesting their importance in the mechanism of mineralization. This work could readily be extended to provide additional novel DNA aptamers for materials synthesis.

Graphical abstract: Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

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Supplementary files

Article information


Submitted
31 Oct 2016
Accepted
22 Dec 2016
First published
22 Dec 2016

Chem. Commun., 2017,53, 1092-1095
Article type
Communication

Precipitation SELEX: identification of DNA aptamers for calcium phosphate materials synthesis

K. R. Baillargeon, K. Meserve, S. Faulkner, S. Watson, H. Butts, P. Deighan and A. E. Gerdon, Chem. Commun., 2017, 53, 1092
DOI: 10.1039/C6CC08687J

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