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Issue 2, 2017
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Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

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Abstract

Single nucleotide polymorphisms (SNPs) play a crucial role as molecular markers in medical and diagnostic application. We demonstrate a nanopore based method for SNP detection at the single molecule level. Designed DNA carriers are used to distinguish DNA strands containing only one single base difference and follow strand displacement kinetics.

Graphical abstract: Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

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Supplementary files

Article information


Submitted
26 Oct 2016
Accepted
29 Nov 2016
First published
29 Nov 2016

Chem. Commun., 2017,53, 436-439
Article type
Communication

Single molecule based SNP detection using designed DNA carriers and solid-state nanopores

J. Kong, J. Zhu and U. F. Keyser, Chem. Commun., 2017, 53, 436
DOI: 10.1039/C6CC08621G

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