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Issue 100, 2016
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Selective Tsuji–Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

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Abstract

The 4,5-dihydropyrazole motif has drawn considerable attention over the years as it was shown to exhibit a plethora of biological and pharmacological properties, including anticancer, antibacterial, antifungal, antiviral, and anti-inflammatory properties. As such, it has been the target of a number of methods and drug discovery programs. We report here a straightforward and highly selective approach featuring a key palladium-catalysed Tsuji–Trost type C-allylation and subsequent intramolecular 1,4-addition of hydrazones.

Graphical abstract: Selective Tsuji–Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

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Supplementary files

Article information


Submitted
10 Oct 2016
Accepted
18 Nov 2016
First published
18 Nov 2016

Chem. Commun., 2016,52, 14490-14493
Article type
Communication

Selective Tsuji–Trost type C-allylation of hydrazones: a straightforward entry into 4,5-dihydropyrazoles

E. H. El Mamouni, M. Cattoen, M. Cordier, J. Cossy, S. Arseniyadis, H. Ilitki and L. El Kaïm, Chem. Commun., 2016, 52, 14490
DOI: 10.1039/C6CC08171A

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