Issue 93, 2016
From the journal:

Chemical Communications

Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts†

Masaru Kondo,ab   Mami Sugimotoa  and  Shuichi Nakamura*ab  

* Corresponding authors

a Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan
E-mail: snakamur@nitech.ac.jp

b Frontier Research Institute for Material Science, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan

Abstract

The catalytic enantioselective Mannich-type reaction of dichloroacetonitrile with imines has been developed. Good yields and enantioselectivity were observed for the reaction with various imines using chiral bis(imidazoline) catalysts. β-Aminonitriles or β-aminoamide were obtained from products without the loss of enantiopurity.

Graphical abstract: Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC07982B
Article type
Communication
Submitted
03 Oct 2016
Accepted
27 Oct 2016
First published
27 Oct 2016

Chem. Commun., 2016,52, 13604-13607

Permissions

Request permissions

Direct catalytic enantioselective Mannich-type reaction of dichloroacetonitrile using bis(imidazoline)-Pd catalysts

M. Kondo, M. Sugimoto and S. Nakamura, Chem. Commun., 2016, 52, 13604 DOI: 10.1039/C6CC07982B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements