Duplications of an iron–sulphur tripeptide leads to the formation of a protoferredoxin†
Based on UV-Vis, NMR, and EPR spectroscopies and DFT and molecular dynamics calculations, a model prebiotic [2Fe–2S] tripeptide was shown to accept and donate electrons. Duplications of the tripeptide sequence led to a protoferredoxin with increased stability. Duplications of primitive peptides may have contributed to the formation of contemporary ferredoxins.
- This article is part of the themed collection: Celebrating our 2019 Prize and Award winners