Jump to main content
Jump to site search

Issue 97, 2016
Previous Article Next Article

Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics

Author affiliations

Abstract

Gambogic acid has shown significant potential as an anti-cancer and anti-inflammatory compound; however, the molecular mechanism underlying the actions of gambogic acid, particularly its cellular target profiles, has not been investigated. In this study, we report the proteome-wide profiling of potential cellular targets of gambogic acid using quantitative mass spectrometry-based chemical proteomics. The target profiles of gambogic acid in living HeLa and K562 cells were identified, which strengthened our understanding of the mode of actions of the phytochemical.

Graphical abstract: Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics

Back to tab navigation

Supplementary files

Article information


Submitted
17 Sep 2016
Accepted
04 Nov 2016
First published
09 Nov 2016

Chem. Commun., 2016,52, 14035-14038
Article type
Communication

Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics

Y. Zhou, W. Li, X. Zhang, H. Zhang and Y. Xiao, Chem. Commun., 2016, 52, 14035
DOI: 10.1039/C6CC07581A

Social activity

Search articles by author

Spotlight

Advertisements