Issue 92, 2016
From the journal:

Chemical Communications

Flavin-mediated photo-oxidation for the detection of mitochondrial flavins†

Dong-Nam Lee,a   Eunjin Kim,b   Jae Hong Lee,c   Jong Seung Kim,*c   Chulhun Kang*b  and  Jong-In Hong*a  

* Corresponding authors

a Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 08826, Republic of Korea
E-mail: jihong@snu.ac.kr
Fax: +82 2 889 1568

b Graduate School of Medical Science, Kyung Hee University, Yongin, Republic of Korea
E-mail: kangch@khu.ac.kr

c Department of Chemistry, Korea University, Seoul 136-701, Republic of Korea
E-mail: jongskim@korea.ac.kr

Abstract

We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M−1 cm−1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.

Graphical abstract: Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

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Article information

DOI
https://doi.org/10.1039/C6CC07483A
Article type
Communication
Submitted
13 Sep 2016
Accepted
25 Oct 2016
First published
01 Nov 2016

Chem. Commun., 2016,52, 13487-13490

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Flavin-mediated photo-oxidation for the detection of mitochondrial flavins

D. Lee, E. Kim, J. H. Lee, J. S. Kim, C. Kang and J. Hong, Chem. Commun., 2016, 52, 13487 DOI: 10.1039/C6CC07483A

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