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Issue 79, 2016
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Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

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Abstract

A photoredox-/copper-catalyzed decarboxylative difluoroacetylation reaction of α,β-unsaturated carboxylic acids has been developed. This reaction produces a variety of difluoroalkylated alkenes in moderate to excellent yields and exhibits satisfactory stereoselectivity and a broad substrate scope at ambient temperature. Furthermore, this decarboxylative difluoroacetylation protocol provides efficient and environment friendly access to the difluoroalkylated alkenes.

Graphical abstract: Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

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Article information


Submitted
29 Jul 2016
Accepted
02 Sep 2016
First published
13 Sep 2016

Chem. Commun., 2016,52, 11827-11830
Article type
Communication

Merging photoredox with copper catalysis: decarboxylative difluoroacetylation of α,β-unsaturated carboxylic acids with ICF2CO2Et

H. Zhang, D. Chen, Y. Han, Y. Qiu, D. Jin and X. Liu, Chem. Commun., 2016, 52, 11827
DOI: 10.1039/C6CC06284A

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