Issue 79, 2016
From the journal:

Chemical Communications

Enantioselective synthesis of β-substituted chiral allylic amines via Rh-catalyzed asymmetric hydrogenation†

Qingli Wang,‡a   Wenchao Gao,‡a   Hui Lv*a  and  Xumu Zhang*ab  

* Corresponding authors

a Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China
E-mail: huilv@whu.edu.cn, xumu@whu.edu.cn

b Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong, China

Abstract

An asymmetric mono-hydrogenation of 2-acetamido-1,3-dienes catalyzed by a Rh–DuanPhos complex has been developed. This approach provides easy access to chiral allylic amines with excellent enantioselectivities and high regioselectivities. The products are valuable chiral building blocks for pharmaceuticals.

Graphical abstract: Enantioselective synthesis of β-substituted chiral allylic amines via Rh-catalyzed asymmetric hydrogenation

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Article information

DOI
https://doi.org/10.1039/C6CC06047A
Article type
Communication
Submitted
22 Jul 2016
Accepted
28 Aug 2016
First published
30 Aug 2016

Chem. Commun., 2016,52, 11850-11853

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Enantioselective synthesis of β-substituted chiral allylic amines via Rh-catalyzed asymmetric hydrogenation

Q. Wang, W. Gao, H. Lv and X. Zhang, Chem. Commun., 2016, 52, 11850 DOI: 10.1039/C6CC06047A

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