Acid-triggered release of doxorubicin from a hydrazone-linked Gd3+-texaphyrin conjugate

Min Hee Lee; Eun-Joong Kim; Hyunseung Lee; Sun Young Park; Kwan Soo Hong; Jong Seung Kim; Jonathan L. Sessler

doi:10.1039/C6CC05673C

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Acid-triggered release of doxorubicin from a hydrazone-linked Gd³⁺-texaphyrin conjugate†

Min Hee Lee,‡*^a Eun-Joong Kim,‡^b Hyunseung Lee,^b Sun Young Park,^a Kwan Soo Hong,*^b Jong Seung Kim*^c and Jonathan L. Sessler*^d

Author affiliations

* Corresponding authors

^a Department of Chemistry, Sookmyung Women's University, Seoul 04310, Korea
E-mail: minheelee@sookmyung.ac.kr

^b Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea
E-mail: kshong@kbsi.re.kr

^c Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: jongskim@korea.ac.kr

^d Department of Chemistry, University of Texas at Austin, Austin, TX 78712-1224, USA
E-mail: sessler@cm.utexas.edu

Abstract

The hydrazone-based Gd³⁺-texaphyrin doxorubicin conjugate 1, releases active doxorubicin at acidic pH values, allowing its components to be followed by two complementary imaging methods, namely Off–On fluorescence enhancement and MR imaging. It thus acts as a promising theranostic agent.

Download options Please wait...

Supplementary files

Supplementary information PDF (1770K)

Article information

DOI: https://doi.org/10.1039/C6CC05673C
Article type: Communication
Submitted: 10 Jul 2016
Accepted: 01 Aug 2016
First published: 01 Aug 2016

Download Citation

Chem. Commun., 2016,52, 10551-10554

Permissions

Request permissions

Acid-triggered release of doxorubicin from a hydrazone-linked Gd³⁺-texaphyrin conjugate

M. H. Lee, E. Kim, H. Lee, S. Y. Park, K. S. Hong, J. S. Kim and J. L. Sessler, Chem. Commun., 2016, 52, 10551 DOI: 10.1039/C6CC05673C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications