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Issue 74, 2016
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“Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

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Abstract

We report a strategy to generate a self-healing and pH responsive hydrogel network between drug-loaded nanoparticles and natural polysaccharides via magnesium–bisphosphonate ligand interactions. The injectable drug depot disassembles in a tumor-specific environment, providing localized uptake of the nanoparticles, which is highly appreciated in drug delivery applications and manufacturing of drug-loaded biomaterials using a syringe-based deposition technique.

Graphical abstract: “Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

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Publication details

The article was received on 05 Jul 2016, accepted on 15 Aug 2016 and first published on 15 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05565F
Citation: Chem. Commun., 2016,52, 11151-11154

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    “Smart” drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium–biopolymer chemistry

    L. Shi, Y. Han, J. Hilborn and D. Ossipov, Chem. Commun., 2016, 52, 11151
    DOI: 10.1039/C6CC05565F

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