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Issue 79, 2016
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Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

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Abstract

Metal exchange is a common strategy to replace the zinc ion of many zinc proteins with other transition metals amenable to spectroscopic investigations. We here demonstrate that in anthrax lethal factor (and likely other zinc proteases), metal exchange is a fast process, and involves the occupation of an inhibitory metal site by the incoming ion prior to the release of zinc.

Graphical abstract: Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

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Supplementary files

Article information


Submitted
30 Jun 2016
Accepted
08 Aug 2016
First published
08 Aug 2016

Chem. Commun., 2016,52, 11748-11751
Article type
Communication

Highly dynamic metal exchange in anthrax lethal factor involves the occupation of an inhibitory metal binding site

C. J. Young and S. Siemann, Chem. Commun., 2016, 52, 11748
DOI: 10.1039/C6CC05460A

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